Product name: Harmine
Latin name: Peganum harmala L.
Specification: Harmine 98%HPLC
Melting Point:262-264 °C(lit.)
Appearance: Light Yellow fine powder
Harmine, also known as telepathine, is a fluorescent harmala
alkaloid belonging to the beta-carboline family of compounds. It
occurs in a number of different plants, most notably the Middle
Eastern plant harmal or Syrian rue (Peganum harmala) and the South
American vine Banisteriopsis caapi (also known as "yage" or
"ayahuasca"). Harmine reversibly inhibits monoamine oxidase A
(MAO-A), an enzyme which breaks down monoamines, making it a RIMA.
Harmine selectively binds to MAO-A but does not inhibit the variant
Monoamines include neurotransmitters (serotonin, dopamine),
hormones (melatonin, epinephrine, norepinephrine) and psychedelic
drugs (psilocybin, DMT and mescaline). By slowing the breakdown of
neurotransmitters, monoamine oxidase inhibitors (MAOIs) can help to
replenish the body's supply of these chemicals, and many MAOIs are
used as antidepressants. Harmine has not been the subject of much
clinical research in the treatment of depression, which could be
due in part to its restricted legal status in many countries, as
well as the existence of synthetic MAOIs with fewer side effects.
P. harmala and B. caapi are both traditionally used for their
psychoactive effects. B. caapi has a tradition of use in
conjunction with plants containing the drug DMT. Traditionally, B.
caapi is consumed as a drink, with or without the DMT-bearing
plants (see Ayahuasca). Ordinarily, DMT is not active when taken
orally, but users report very different effects when MAOIs are
present in such beverages. Harmine and substances containing it
have been used in conjunction with many other drugs by modern
experimenters. Many hallucinogens appear to exhibit increased
potency when used in this way.
Harmine is also a useful fluorescent pH indicator. As the pH of its
local environment increases, the fluorescence emission of harmine
With the radioisotope carbon-11 harmine is used in positron
emission tomography neuroimaging to examine its binding to MAO-A.
Harmine found in root secretions of Oxalis tuberosa has been found
to have insecticidal properties.
Harmine has been found to increase EAAT2 glutamate pump expression
in central nervous system, therefore reducing glutamate toxicity.
Harmine showed cytotoxicity against HL60 and K562 cell lines. This
could explain the cytotoxic effect of P. harmala on these cells.
Effects on bone and cartilage
Harmine was shown to promote differentiation of osteoblasts
(bone-forming cells), and chondrocytes (cells in the cartilage).
It was also shown to inhibit osteoclastogenesis (the formation of
bone resorbing cells).
Storage: Store in sealed containers at cool & dry place.
Protect from light, moisture and pest infestation
Shelf life: 2 year when properly stored.
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